There have been a number of Popeye comic books, from Dell, King Comics, Gold Key Comics, Charlton Comics and others, originally written and illustrated by Bud Sagendorf. In the Dell comics, Popeye became something like a freelance police assistant, fighting the Mafia and Bluto's criminal activities. The new villains included the Ming dwarves, who were identical.

Popeye appeared in the British "TV Comic" series, a News of the World publication, becoming the cover story in 1960 with stories written and drawn by 'Chick' Henderson. Bluto was referred to as Brutus and was Popeye's only nemesis throughout the entire run.

A variety of artists have created Popeye comic book stories since then; for example, George Wildman drew Popeye stories for Charlton Comics from 1969 until the late 1970s. The Gold Key series was illustrated by Wildman and scripted by Bill Pearson, with some issues written by Nick Cuti.

In 1987, Ocean Comics released the Popeye Special written by Ron Portier with art by Ben Dunn. The story presented Popeye's origin story and attempted to tell more of a lighthearted adventure story as opposed to using typical comic strip style humor. The story also featured a more realistic art style and was edited by Bill Pearson, who also lettered and inked the story as well as the front cover.^[8] A second issue, by the same creative team, followed in 1988. The second issue introduced the idea that Bluto and Brutus were actually twin brothers and not the same person.^[9] In 1999, to celebrate Popeye's 70th anniversary, Ocean Comics revisited the franchise with a one-shot comic book, entitled The Wedding of Popeye and Olive Oyl, written by Peter David. The comic book brought together a large portion of the casts of both the comic strip and the animated shorts, and Popeye and Olive Oyl were finally wed after decades of courtship. However, this marriage has not been reflected in all media since the comic was published.

In 1989, a special series of short Popeye comic books were included in specially marked boxes of Instant Quaker Oatmeal, and Popeye also appeared in TV commercials forQuaker Oatmeal, which featured a parrot delivering the tag line "Popeye wants a Quaker!". The plots were similar to those of the films: Popeye loses either Olive Oyl or Swee'Pea to a musclebound antagonist, eats something invigorating, and proceeds to save the day. In this case, however, the invigorating elixir was not his usual spinach, but rather one of four flavors of Quaker Oatmeal. (A different flavor was showcased with each mini-comic.) The comics ended with the sailor saying, "I'm Popeye the Quaker Man!", which offended members of the Religious Society of Friends or Quakers. Members of this religious group (which has no connection to the cereal company) are pacifists and do not believe in using violence to resolve conflicts. For Popeye to call himself a "Quaker man" after beating up someone was offensive to the Quakers and considered a misrepresentation of their faith and religious beliefs. After a brief protest, the Quaker Oatmeal Company pulled the comic books and commercials in 1990, and the promotional campaign remains little-known.