The first^{[citation needed]} animated film was created by Charles-Émile Reynaud, inventor of the praxinoscope, an animation system using loops of 12 pictures. On October 28, 1892 at Musée Grévin in Paris, France he exhibited animations consisting of loops of about 500 frames, using his Théâtre Optique system - similar in principle to a modern film projector.

The first animated work on standard picture film was Humorous Phases of Funny Faces (1906) by J. Stuart Blackton. It features what appears to be a cartoonist drawing faces on a chalkboard, and the faces apparently coming to life; whereas it was actually black line art drawn on white paper and then printed as a film-negative to look like white chalk.^{[citation needed]}

Fantasmagorie, by the French director Émile Cohl (also called Émile Courtet), is also noteworthy. It was screened for the first time on August 17, 1908 at Théâtre du Gymnase in Paris. Émile Courtet later went toFort Lee, New Jersey near New York City in 1912, where he worked for French studio Éclair and spread its technique in the US.

Influenced by Cohl, Russian scientist Ladislas Starevitch started to create animated films using dead insects with wire limbs. In 1911 he created "The Cameraman's Revenge", a complex tale of treason, suicide and violence between several different insects. It is a pioneer work of puppet animation, and the oldest known example of an animated film of such dramatic complexity, with characters filled with motivation, desire and feelings.

In 1914, American cartoonist Winsor McCay released Gertie the Dinosaur, an early example of character animation.